Recent Publications

Landfear, S.M. and Zilberstein, D. Sensing What’s Out There – Kinetoplastid Parasites. Trends in Parasitol. 35: 274-277 (2019).

Zilberstein, D. and Nitzan Koren, R. Host-Free Systems for Differentiation of Axenic Leishmania. Meth. Mol. Biol 1971: 1-8 (2019).

Pawar, H., Puri, M., Fischer-Weinberger, R., Madhubala, R. and Zilberstein, D. The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania. PLoS NTD, 13: e0007304 (2019).

Zilberstein, D. Nutrient Transport and Sensing as Pharmacological Targets for Leishmaniasis. In Drug Discovery for Leishmaniasis, L. Rivas, Carmen, G., ed. (United Kingdom: The Royal Society of Chemistry), pp. 282-296, (2018).

Liburkin-Dan, T., Schlisselberg, D., Fischer-Weinberger, R., Pescher, P., Inbar, E., Rentsch, D., Späth, G.F., Myler, P.J. and Zilberstein, D. Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania. Molecular and Biochemical Parasitology, 222, 1-5 (2018).

Mathieu, C., Macedo, J. P., Hurlimann, D., Wirdnam, C., Haindrich, A. C., Suter Grotemeyer, M., Gonzalez-Salgado, A., Schmidt, R. S., Inbar, E., Maser, P., Butikofer, P., Zilberstein, D., and Rentsch, D. Arginine and Lysine Transporters Are Essential for Trypanosoma brucei. PLoS One, 12, e0168775 (2017).

Goldman-Pinkovich, A., Balno, C., Strasser, R., Zeituni-Molad, M., Bendelak, K., Rentsch, D.,  Ephros, M., Wiese, M., Jardim, A., Myler, P.J., Zilberstein, D. An arginine deprivation response pathway is induced in Leishmania during macrophage invasion., PLoS Path, 14, e1005494 (2016).

Bachmaier, S., Witztum, R., Tsigankov, P., Koren, R., Boshart, M., Zilberstein, D. Protein kinase A signaling during bidirectional axenic differentiation of Leishmania, International Journal of Parasitology 46, 75-82 (2016).

Schlisselberg, D., Mazarib, E., Inbar, E., Rentsch, D., Myler, P. J., Zilberstein, D. Size does matter: 18 amino acids at the N-terminal tip of a neutral amino acid transporter (LdAAP24) in Leishmania determine substrate specificity. Scientific Reports, 5, 16289-16298 (2015).

Zilberstein, D. Proteomic analysis of post translational modifications using iTRAQ in Leishmania. Methods Mol Biol, 1201, 261-268 (2015).

Gomez, M.A., Navas, A., Marquez, R., Rojas, L., Vargas, D.A., Blanco, V., Koren, R., Zilberstein, D., Saravia, N. Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: Impact on intracellular parasite survival. Antimicrob. Agen. Chemot., 69, 139-149, (2014).

Porcel, B.A. Denoeud, F., Opperdoes, F., Noel, B., Madoui, M.A., Hammarton, T.C., Field, M.C., Da Silva, D., Couloux, A., Poulain, J., Katinka, M., Jabbari, K., Aury, J.M., Campbell, D.A., Cintron, R., Dickens, N.J., Docampo, R., Sturm, N.R., Koumandou, V.L., Fabre, S., Flegontov, P., Lukeš, J., Michaeli, S., Mottram, J.C., Szöőr, B., Zilberstein, D., Bringaud, B., Wincker, B, Dollet, M. The streamlined genome of Phytomonas spp. relative to human pathogenic kinetoplastids reveals a parasite tailored for plants. PLoS Gen., 10, e1004007, (2014).

Tsigankov, P., Gherardini, F.P., Helmer-Citterich, M., Späth, G.F., Myler, P.J., Zilberstein, D. Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends. Mol. & Cell. Prot., 13, 1769-1786 (2014).

Mathieu, C., Gonzalez Salgado, A., Wirdnam, C., Meier, S., Suter Grotemeyer, M., Inbar, E., Maser, P., Zilberstein, D., Sigel, E., Butikofer, P., and Rentsch, D. Trypanosoma brucei eflornithine transporter AAT6 is a low affinity, low selective transporter for neutral amino acids. Biochem J., 463, 9-18 (2014).

Prati*, F., Goldman-Pinkovich*, A., Lizzi, L., Belluti, B., Koren, R., Zilberstein, D., Bolognesi, M.L. Quinone-amino acid conjugates probing Leishmania amino acid transporters. Plos One, 9, e107994 (2014).

Tsigankov, P., Gherardini, P. F., Helmer Citterich, M., Spath, G. F., Zilberstein, D. Phosphoproteomic analysis of differentiating Leishmania parasites reveals unique stage-specific phosphorylation motif. J. Prot. Res. 12, 3405-3412, (2013).

Inbar, E., Schlisselberg, D., Suter Grotemeyer, M., Rentsch, D. and Zilberstein, D. A versatile proline-alanine transporter in the unicellular pathogen Leishmania donovani regulates amino acid homeostasis and osmotic stress responses. Biochem. J. 449, 555-566, (2013).